**Open at St. Joseph Mercy Hospital Ann Arbor Only**

Inclusion:
*Locally recurrent or metastatic Breast Cancer
*Receipt of first systemic cytotoxic chemotherapy and/or targeted therapy among those with HER2-normal disease or first hormone therapy among those with HR-positive disease for the treatment of locally recurrent or metastatic disease, no greater than one month prior to enrollment.

Exclusion:
*Any medical condition, including mental illness or substance abuse, deemed by the investigator to be likely to interfere with a patient's ability to provide informed consent or comply with the treatment.
*Concurrent participation in a blinded clinical trial.