| SWOG-C10403 | An Intergroup Phase II Clinical Trial for Adolescents and Young Adults with Acute Lymphoblastic Leukemia (ALL) (1540)-
Eligibility: click to view information
DISEASE CHARACTERISTICS:
Newly diagnosed acute lymphoblastic leukemia (ALL)
B-precursor or T-precursor ALL
No Burkitt type leukemia (FAB L3; SIg positive; t(8;14) or variant)
No known Ph+ ALL at time of diagnosis
Enrollment on CALGB-C10001 (or its successor trial) for CALGB patients with Philadelphia-positive ALL take priority over enrollment on this protocol
Patients enrolled on this study but are later found to meet the following criteria for Ph+ ALL eligibility criteria for protocol CALGB-C10001 (or its successor trial) are removed from this study and enrolled on CALGB-C10001 (or its successor study):
BCR-ABL fusion transcript determined by FISH or RT-PCR
t(9;22)(q34;q11) or variant determined by cytogenetics
All CALGB patients are required to participate in CALGB-8461
All SWOG patients are required to participate in SWOG-9007
PATIENT CHARACTERISTICS:
ECOG performance status 0-2
No Down syndrome
PRIOR CONCURRENT THERAPY:
No prior therapy for acute leukemia except emergency therapy (i.e., corticosteroids or hydroxyurea) for blast cell crisis, superior vena cava syndrome, or renal failure due to leukemic infiltration of the kidneys
Single-dose intrathecal cytarabine is allowed prior to registration for patient convenience provided systemic chemotherapy begins within 72 hours of intrathecal therapy
Prior steroid therapy allowed
- Consent Forms: C10403 Consent
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