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Active Clinical Trials: Hematology- Acute Lymphocytic Leukemia (ALL)

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ProtocolTitle
SWOG-C10403An Intergroup Phase II Clinical Trial for Adolescents and Young Adults with Acute Lymphoblastic Leukemia (ALL) (1540)
  • Eligibility: click to view information

    DISEASE CHARACTERISTICS:

    Newly diagnosed acute lymphoblastic leukemia (ALL)

    B-precursor or T-precursor ALL

    No Burkitt type leukemia (FAB L3; SIg positive; t(8;14) or variant)

    No known Ph+ ALL at time of diagnosis

    Enrollment on CALGB-C10001 (or its successor trial) for CALGB patients with Philadelphia-positive ALL take priority over enrollment on this protocol

    Patients enrolled on this study but are later found to meet the following criteria for Ph+ ALL eligibility criteria for protocol CALGB-C10001 (or its successor trial) are removed from this study and enrolled on CALGB-C10001 (or its successor study):



    BCR-ABL fusion transcript determined by FISH or RT-PCR

    t(9;22)(q34;q11) or variant determined by cytogenetics

    All CALGB patients are required to participate in CALGB-8461

    All SWOG patients are required to participate in SWOG-9007

    PATIENT CHARACTERISTICS:



    ECOG performance status 0-2

    No Down syndrome

    PRIOR CONCURRENT THERAPY:



    No prior therapy for acute leukemia except emergency therapy (i.e., corticosteroids or hydroxyurea) for blast cell crisis, superior vena cava syndrome, or renal failure due to leukemic infiltration of the kidneys

    Single-dose intrathecal cytarabine is allowed prior to registration for patient convenience provided systemic chemotherapy begins within 72 hours of intrathecal therapy

    Prior steroid therapy allowed



  • Consent Forms: C10403 Consent
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